This Week in Startups
This Week in Startups
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
Jason Calacanis
PodcastAI
PodcastAI

AI Progress and Impact on Ecosystem Players with CapitalG’s Jill Chase | AI Basics with Google Cloud

Apr 17, 2025 • 25 mins

In this episode of AI Basics, Jason sits down with CapitalG partner Jill Chase to break down how AI is reshaping the startup ecosystem — from founders to investors to incumbents. They cover how CapitalG (Alphabet’s independent growth fund) thinks about the AI stack, why speed alone isn’t enough for startups today, and how to build durable advantages in a world where anyone can copy your product. Jill shares insights from portfolio companies like Motif (next-gen CAD for architecture) and Abridge (AI-powered doctor’s scribe), plus how startups can use AI “in the business” (product) and “on the business” (ops, GTM, etc). They also explore the transition from copilots to agents — and what that means for the next wave of software. If you’re building or investing in AI, this is a must-watch.

Key Points

  • AI is revolutionizing startups by enabling rapid testing, iteration, and product development, significantly lowering the barrier to entry for new companies.
  • Sustained differentiation and building trust with customers are crucial for startups to maintain a competitive edge in the rapidly evolving AI landscape.
  • The transition from AI copilots to fully autonomous agents is underway, with models gradually taking on more complex tasks and improving efficiency across various domains.
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