It’s a boat, it’s a plane, it’s REGENT’s Seafarer | E2205

Today’s show: *The key to avoiding long airport delays? Low-altitude sea planes! Why didn’t you think of that? We’ve got an awesome line-up of TWiST 500 founders giving us an inside glimpse inside their startups on this Friday special edition. FIRST: Billy Thalheimer of REGENT introduces us to their aircraft/boat hybrid The Seaglider, and walk us through how it all works, AND why they’re operating in BOTH the commercial and defense sectors from their Rhode Island HQ. THEN, we’ve got Convexia co-founder Ayan Parekh showcasing how they’re using a collective of specialist AI agents to exploit other pharma labs’ leftovers and turn them into new drugs and treatments for rare diseases. FINALLY, Hunter Leath of Archil joins the show to tell us why efficient utilization of cloud data remains a surprisingly complex, and unsolved problem. His solution? Caching-as-a-Service! Find out how it all works, and why pre-caching is SO difficult to do, in this TWiST exclusive chat.

Is investing REALLY the hardest job in tech? A TWIST VC Roundtable (ft. Deedy Das and Jay Eum) | E2204

In this episode, Jason Calacanis is joined by Didi Doss and Jay from GFT Ventures to explore the shifting landscape of venture capital and startup ecosystems. They delve into Sequoia's leadership change and Roloff Botha's legacy, discussing the evolution of capital allocation and the rise of global decacorns. The panel examines the increasing expectations for pre-seed funding, the disparities in venture funding, and the challenges of overpaying while ensuring returns for LPs. They also touch on the impact of AI on customer retention and the growth of companies like Anthropic and OpenAI. The episode wraps with insights into the rise of AI-generated content and storytelling in startup marketing.

Sending datacenters into orbit | E2203

👉 Register here to join the Founder University Japan kickoff! https://luma.com/cm0x90mk * Today’s show: *Starcloud has started sending AI chips into orbit. So is this where the datacenters the power AI will one day live? And does wifi work in the vacuum of space? We’re asking the TOUGH questions. PLUS Jason and Alex are doing a deep dive on all this week’s OpenAI news. Will they ever be able to pay back all these GPU purchases? What happens to the wider economy on the off chance they don’t thrive? And what’s with these rumors that ChatGPT has stopped giving medical or legal advice? All that and a look at TrustMRR (and why Jason advises you not to publicly share your Stripe), why Jason thinks Netflix should buy CNN, our hosts favorite Nazi hunter movies, and MORE.

What will be OpenAI’s IPO price? Place ya bets! | E2202

*Polymarket’s sharps are already placing bets on when ChatGPT maker OpenAI will go public… and Jason and Alex want in on this action. They’re placing side wagers on how the House that Sam Altman built will be valued once it finally goes public. PLUS find out why Amazon is Jason’s stock pick for the next five years… Why startups are starting to release their own foundation models, and what this means for major players like OpenAI and Anthropic… AND Producer Oliver stops by with an in-depth look at the music-generating Suno app.

Grammarly is now Superhuman! CEO Shishir Mehrotra explains the rebrand | E2201

In this episode, Alex Wilhelm, Jason Calacanis, and Shashir Mehrotra explore evolving work culture, highlighting employee care, company culture, and four-day workweeks. They examine small company efficiency and compare market leaders' work cultures. Shashir introduces Superhuman Go, focusing on AI assistants and personalization in productivity. They tackle audience questions on pricing, style, and privacy, and discuss NVIDIA's market cap, OpenAI's revenue, and Microsoft's investment in OpenAI. The conversation also covers autonomous vehicles, robotics, economic insights, and previews upcoming big tech earnings and AI discussions.

Jason Unpacks Sequoia’s New Funds"| E2199

In this episode, we dive into hyperscaler earnings and AI's role in cloud computing. We explore holiday season predictions and trends in online learning investments, addressing AI-generated fraud concerns. Discover how AI tools analyze earnings calls and the growth of drone shows globally. Learn about Tesla's synthetic data training for Full Self-Driving and new partnerships in autonomous driving. We also discuss media bias, Sequoia Capital's latest funds, and the effect of political statements on startups. Finally, we update on the AI trading competition, Microsoft's AI pricing strategy, and ethical business practices, wrapping up with a call for listener feedback.

If you’re not working 9-9-6, are you working hard enough? | E2198

This episode explores the intersection of sports, betting, and technology, beginning with insider information on LeBron James' injury and its implications for betting and fantasy sports. The discussion shifts to a poker cheating scandal involving NBA figures, examining the legality and monitoring of high-stakes celebrity games. The episode also touches on China's demanding 996 work culture and features insights from Presh on storyboarding methods. Anthropic's deal with Google highlights AI infrastructure investments, while cloud infrastructure's evolution is analyzed through Dropbox's history and David Heinemeier Hansson's views on AWS spending. The episode concludes with a cost-benefit analysis of cloud providers.

Amazon’s “Age of Efficiency,” LLM distribution, AI wearable worries, and more with Elad Gil | E2197

In this episode, Jason Calacanis and Elad Gil explore the startup and AI landscape, discussing efficiency, revenue growth, and AI's role in book translation and computing. They examine AI's energy costs, Middle East startup ecosystems, and Nivan's IPO journey. The episode also covers AI's impact on enterprises, Amazon's automation, workforce implications, and AI's future in consumer tech and finance. They touch on regulatory debates in AI and tech acquisitions, wrapping up with insights on AI regulation compared to other industries.

Just how frothy is the AI Bubble anyway? | E2195

Jason, Alex, and Lon engage in a lively discussion on the potential existence of an AI bubble, examining historical patterns of economic bubbles and the roles economists and bankers play in these scenarios. They delve into signs of an AI investment bubble, exploring corporate spending and market frothiness, while debating if this cycle could be the greatest in tech history. The episode also covers the AWS outage's impact, strategies for multi-cloud resilience, and the challenges of verifying AI-generated content amidst misinformation. Additional topics include Zuckerberg's investment insights, large-scale protests, and AI's role in market trading. They wrap up with thoughts on cultural impacts of Aaron Sorkin's sequel to "The Social Network".

Deel’s growth overshadows SpyGate, Claude learned new skills & the “momentum is moat” debate | E2194

In this episode, we dive into market chaos and business strategies. Jason discusses the ski season and Open Snow app, and a shift to short, direct calls amid market changes. The team explores AI's expanding opportunities and the potential for trillion-dollar AI companies. They analyze Deel's $300M raise and its industry impact. Roloff Botha joins to discuss venture capital dynamics. We cover startup valuation, growth prospects for Rippling and Deel, and capital strategies. Anthropic's AI skills and applications are highlighted, along with collaboration in LLMs. Jason shares his health journey, and the episode wraps up with a focus on startups, AI, and data balance.

Legendary VC Steve Jurvetson looks ahead at neutral networks, Tesla, nuclear power, and more | E2193

Today’s show: *On a very special TWiST, Jason’s joined by “one of the greatest investors in in the history of VC,” Steve Jurvetson of Future Ventures. Together, they look back at some of Steve’s earliest investments and learnings, the promise and ultimate failure of nanotech, breaking down the AI hype cycle, the primacy of neural networks, the return of nuclear power, why “AI safety” might be illusory, and much more. It’s a packed show full of deep insights from one of the greatest minds in technology today. Do not miss this ep! Subscribe to the TWiST500 newsletter: [https://ticker.thisweekinstartups.com](https://ticker.thisweekinstartups.com/) Check out the TWIST500: [https://www.twist500.com](https://twist500.com)

What Ramp’s data tells us about AI, unemployment and more with CEO Eric Glyman | E2192

In this episode, the discussion kicks off with hedge fund speculation and Trump's tariff announcement, exploring their effects on the market and cryptocurrency reactions. Eric Glyman, CEO of Ramp, joins to provide insights into the SaaS market and how Ramp leverages data to drive expense reduction and financial automation through AI. The conversation delves into AI's impact on employment, static team sizes, and the evolution of the job market. The episode also covers SaaS revenue expectations, corporate expense policies, and Ramp's agent adoption. In addition, the YC handshake deal controversy and alternatives to YC are examined, alongside a tribute to leadership values exemplified by Dave Goldberg.

Figure’s 03 Chore-bot, Jake Paul Sora takeover, ChatGPT app integrations, and more | E2191

Today's show covers a range of topics from the latest developments in AI to the future of humanoid robots. Jason and the team dive into the rapid success of the Sora app and its celebrity involvement, alongside discussions on OpenAI’s ChatGPT integrations and Spotify’s AI DJ. They explore the potential of AI tools in platforms like Canva and Figma, and Jason shares his insights on AI assistants in business. The episode also tackles the American AI landscape, open source models, and the benefits of in-person work. Plus, they highlight the impact of startups on the postal service and explore apprenticeship opportunities with Extern.com.

Battery Power for Texans with Zach Dell, plus Tim Apple is LEAVING? and a Tesla fan update | E2190

Today’s show: Zach Dell of Base Power joins us at the top of today’s show to talk about building batteries in Austin, that $1 billion investment, and why an “all of the above” energy strategy is the only way forward. PLUS Jason and Alex’s thoughts on that Tesla non-upside down car announcement, growing resentments toward AI datacenters, Chinese robots actually going on sale, Tim Cook’s potential Apple exit, xAI’s Nvidia agreement and MUCH MORE.

OpenAI’s latest “bizarre” mega-deal, previewing Tesla’s big announcement and more | E2189

Today’s show: How many weirdly circular mega-deals is OpenAI going to sign this year? On a new TWiST, Jason and Alex consider OpenAI’s latest agreement with AMD, how the biggest American companies keep trading cash and chips back and forth, and whether or not the entire AI economy might be a house of cards. PLUS what kind of fan/leafblower tech is Tesla working on… what can Jevons Paradox tell us about the AI landscape… how easy is it to master games in the YC Arena… and WHY has NASA never built a base on the moon? We’re asking the TOUGH QUESTIONS so you don’t have to, only on the #1 tech podcast, “This Week in Startups.”

Sora app review, Perplexity’s Comet is FREE, and which AI tools reign supreme? | E2188

Today’s show: Is Sora not just a copyright-killer but a TikTok-killer? Hear our review! The “This Week in Startups” team has been playing around inside OpenAI’s viral app, which just hit #1 in the iOS Store. See all of Lon’s creations, explore the land beyond the Uncanny Valley, and find out why the hottest new social app could stand to be a bit more social. PLUS Brave surpasses 100M MAUs… why Jason would sell ALL his OpenAI shares right away, Apple pulls the ICEBlock app from the App Store, AND how one founder hacked his local coffee shop to network and even get face time with a few VCs! It’s all happening of a fast-paced Friday TWiST.

Sora 2, Tilly Norwood, and the New Slop Era | E2187

Today’s show: Sora 2 will generate a video of whatever you like and respects no IP (unless they opt out) On a brand new TWiST, Jason and Alex check out Sora 2, the latest text-to-video app from TWiST 500 mainstays OpenAI, and look at some of the video videos that have already emerged from the TikTok-style scrolling video app. (TikSlop?) THEN we’re considering the case of “AI actress” Tilly Norwood, and whether her big debut is a legit shift in the world of entertainment or just a marketing gimmick-slash-sales pitch. PLUS Jason’s thoughts on the Wealthfront IPO, how Spotify shifted the entire music economy, Jason’s pitch for making bets with stock purchases, why Americans need more financial literacy, AND another check-in with the sharps over at Polymarket.

Breaking the Sound Barrier with Blake Scholl from Boom Supersonic | E2186

Today’s show: How do you get investors excited about jets when they’re hyper-focused on new AI tools? In a fresh TWiST 500 interview, Alex sits down with Blake Scholl of Boom Supersonic to talk about the Overture, the world’s fastest plane that recently broke the sound barrier over the Mojave Desert. (That’s a first for a private company, rather than a military or government.) Hear about the secrets to avoiding a noisy and disruptive sonic boom, using satellites to set the most efficient routes, designing the Overture’s complex engine, dispelling the common myth that hardware startups are money pits and much much more. PLUS we’ve got two brand new companies entering our Gamma Pitch Deck Competition. Time to see how they stack up to our first impressive entrant, Where2Wheel.

Why New Yorkers hate AI Friends, Producer Claude gets an update, and the value of human writers in the Age of Slop | E2185

Today’s show: Friend’s new AI pendant just wants to be your new pal. So why do New Yorkers hate them? On a brand-new TWiST, Jason and Alex consider the Friend AI pendant, which listens to everything you say all day and then sends you snarky texts about it. WIRED says it’s unhelpful and will make your friends hate you. New Yorkers are so sick of their aggressive subway ads, they’re tagging them with graffiti. But what do Jason and Alex think of the wearable companion? PLUS the value of bringing your last team with you to your new project… why partnerships often lead to purchases… Producer Claude got an upgrade… two fresh TWiST 500 companies… the rise and fall and further fall of Tai Lopez… AND Jason explains the rules of private jets.

Is there an AI coding bubble? Plus Meta’s new SlopTok product, Neon’s divisive app shuts down, and more | E2184

Today’s show: Factory, a Sequoia-backed producer of AI agents for programming, raised $50 million at a $300 million valuation. So Jason and Alex are wondering… how much capital is TOO MUCH? We’re going deep on a question that often perplexes founders: How would weigh a HUGE potential market against STIFF pre-existing competition. PLUS that Neon app that records your calls deleted itself, why AI ISN’T taking away all the radiology jobs yet, how inherent biases impact everyone’s view of the economy, ChatGPT may be getting ads very soon, and MUCH MUCH MORE.