From Blood Transfusions to Burritos, How Zipline is Automating Delivery | E2238
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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
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From Blood Transfusions to Burritos, How Zipline is Automating Delivery | E2238

E2238 • Jan 21, 2026 • 64 mins

On today’s TWIST episode, Alex interviews two of the top startup co-founders: Keller Cliffton of Zipline and Anastasis Germanidis of Runway. Zipline announced its $600 million raise at a $7.6 BILLION valuation. Kellers breaks down the origins, economics, and future of Zipline’s contrarian bet in drone delivery. What was science fiction a decade ago is now a regular part of life for many. In fact, Zipline operates more flights than United! Zipline is set to leapfrog the car delivery apps AND self driving cars with the superior economics of drone delivery. It is much cheaper to transport your burrito in a lightweight drone than a 6,000 pound self driving car! Then, Alex is joined by Anastasis Germanidis, the CTO and co-founder of Runway, to explain why the next frontier of generative AI is world models!

Key Points

  • Zipline's innovative drone delivery system is revolutionizing logistics by offering ultra-fast, environmentally friendly, and highly accurate delivery services, expanding from medical supplies to everyday consumer products.
  • The development of world models, as discussed by Runway, represents a significant advancement in AI technology, enabling continuous, interactive simulations that can be applied to diverse fields such as robotics, gaming, and real-time video generation.
  • For startup founders, having technical co-founders who can write code and rapidly iterate on product development is crucial, as it significantly increases the chances of success and adaptability in the competitive tech landscape.
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Speakers

Keller Rinaudo Clifton

Guest • 34%

Alex Wilhelm

Host • 26%

Jason Calacanis

Host • 11%

Anastasios (Tasos) Glaros

Guest • 24%

Partners

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Transcript

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