How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241
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How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

E2241 • Jan 28, 2026 • 56 mins

On TWiST’s first Cannabis Roundtable, Jason is joined by three top Cannabis founders and investors: Ford Smith of Ultranative, Andrew Duffy of Sparkplug, and Socrates Rosenfeld of Jane. How will the regulatory environment and the move to Schedule III change the industry? Are those regulations shaping consumption? How are investors thinking about cannabis startups given the difficulty with exits? Most importantly, what’s the deal with the increasing potency of cannabis? Each guest has their own perspective, Andrew sees it as a natural reaction from CPG brands to power users, Ford points to “flyover” operators unconcerned with long-term health of the industry, while Socrates refers to moonshine drinking during the prohibition to say that regulations create these problems.

Key Points

  • The cannabis industry is poised for significant growth and federal legalization, which could remove onerous tax burdens and open up interstate commerce, drastically changing the market landscape.
  • The emergence of highly potent cannabis products like shatter and live resin, reminiscent of the over-concentration seen in past prohibition scenarios, underscores the need for smart regulation to ensure consumer safety.
  • Despite the challenges and setbacks from overregulation and market saturation, the cannabis industry continues to innovate, with companies like Jane and Sparkplug leading efforts to provide consistent, transparent, and safe consumer experiences.
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