This Week in Startups
This Week in Startups
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
Jason Calacanis
PodcastAI
PodcastAI

Sending datacenters into orbit | E2203

E2203 • Nov 3, 2025 • 78 mins

👉 Register here to join the Founder University Japan kickoff! https://luma.com/cm0x90mk * Today’s show: *Starcloud has started sending AI chips into orbit. So is this where the datacenters the power AI will one day live? And does wifi work in the vacuum of space? We’re asking the TOUGH questions. PLUS Jason and Alex are doing a deep dive on all this week’s OpenAI news. Will they ever be able to pay back all these GPU purchases? What happens to the wider economy on the off chance they don’t thrive? And what’s with these rumors that ChatGPT has stopped giving medical or legal advice? All that and a look at TrustMRR (and why Jason advises you not to publicly share your Stripe), why Jason thinks Netflix should buy CNN, our hosts favorite Nazi hunter movies, and MORE.

Key Points

  • Large language models outperform human doctors in quality and empathy, although they are not yet ready to fully replace them for personalized medical advice.
  • Warner Brothers Discovery is considering splitting up its assets, with Netflix showing interest in acquiring its IP while potentially spinning off the cable networks.
  • Founders should send regular investor updates, detailing runway, burn rate, and specific requests for help, to maintain strong relationships and ensure transparency.
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