IPO Mania hits the TWiST 500! Three companies are ready to go public | E2206
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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
Jason Calacanis
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IPO Mania hits the TWiST 500! Three companies are ready to go public | E2206

E2206 • Nov 10, 2025 • 65 mins

Today’s show: *Three of our favorite TWiST 500 startups — Ledger, 1Password, AND Mercury — are circling IPOs. Find out why the cybersecurity space remains so hot… AND why Jason says you really need to have multiple banks. PLUS Marc Andreessen called The Pope an AI Doomer on X, then thought better of it. We’re tracking the entire viral controversy… SPEAKING OF viral feuds, allegations are FLYING around about recently-funded AI agent makers Giga. Does the startup pose some genuine red flags, or was it just a questionable launch video? AND why Alex and Jason remain optimistic the AI vibes could turn around, presentation maker Gamma is growing FAST, plus an update on Jason and Alex’s Polymarket IPO wager…

Key Points

  • The rise of AI and automation is creating anxiety about job displacement and prompting a trend towards self-reliance and entrepreneurship among college graduates.
  • The success of startups like Gamma, 1Password, and Mercury showcases how AI and tech companies can achieve significant growth and prepare for potential IPOs, even in a challenging economic environment.
  • The recent controversies and high valuations in the tech industry highlight a peak level of entitlement and bubble-like behavior, raising questions about sustainability and the future of major players like OpenAI.
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