This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

AUTOMATING HEALTH CARE, THERMODYNAMIC COMPUTING, AND PRODUCT VELOCITY | E2155

Jul 23, 2025 • 81 mins

Today’s show: TWiST is back with a three more hugely insightful (and also fun!) founder interviews. First up, Trey Holterman from Tennr tells us why getting in to see a specialist is so time consuming, and how AI is making the entire health care industry more streamlined. THEN Gill Verdon from Extropic AI unpacks deterministic vs. probabilistic computing, and how thermodynamics can make everything from robots to VR more effective. FINALLY, Tyler Denk from our fav newsletter platform Beehiiv walks us through their future roadmap, and explains why they’re adding new features SO OFTEN. It’s a packed episode full of fresh insights for founders. Check it out!

Key Points

Healthcare technology company Tenor is revolutionizing the patient referral process by leveraging AI to reduce friction, improve conversion rates, and ensure timely patient care.
Extropic is pioneering a new era of probabilistic computing with thermodynamic chips, aiming to offer a highly energy-efficient alternative to current AI computation, potentially reshaping the market for AI hardware.
Beehive is rapidly expanding its product suite with a new website builder and ad network, aiming to become a comprehensive platform for content creators and publishers, while maintaining strong ARR growth and exploring new revenue streams.

Speakers

Alex Wilhelm

Host • 31%

Trey Holterman

Guest • 20%

Gil Verdant

Guest • 25%

Tyler Dank

Guest • 17%

Partners

Chapters

0:00	Introduction to the healthcare referral funnel analogy
1:57	Introduction to the episode and Twist 500 project
2:26	Discussion on the healthcare market and Tenor's role
3:40	Trey Holterman on Tenor's mission and the medical referral problem
6:34	Specialist referrals inefficiency and Tenor's impact
10:22	Sponsor: Squarespace
11:45	Scale of the US healthcare referral problem
14:05	Tenor's AI solution for referral inefficiencies
18:20	Patient perspective on Tenor's system and value proposition
20:05	Making startups legitimate and Tenor's visibility network
22:28	Reaction and future plans for Tenor
25:54	Challenges in selling to regulated industries
29:59	Sponsor: AWS Activate
31:20	NVIDIA's AI chip market position and introduction of XTropic
37:24	Computing approaches: Probabilistic vs deterministic
39:12	Energy-based models, neural networks, and brain efficiency
44:02	Scaling chip efficiency and commercial growth
49:04	Room temperature thermodynamic computing and AI at the edge
56:13	Market potential for new computing technologies
56:46	Sponsor: Gamma pitch deck competition
58:52	Substack and Beehive funding and growth overview
1:02:04	Beehive's market opportunities and new website builder
1:04:12	Comparing Beehive to other platforms
1:06:13	Future prospects and growth potential of Beehive
1:09:38	Expanding content types in email newsletters
1:11:00	Three pillars of Beehive's growth strategy
1:14:15	Challenges and risks for Beehive and Substack vs traditional media

Transcript

Loading transcript...

- / -